The field of PROTACs continues to evolve. A recent Nature Communications paper describes another self-assembling nano-PROTAC that co-degrades androgen receptor (AR) and HSP90 and shows promise for treatment of castration-resistant prostate cancer (CRPC). To save your precious time, here is my summary and highlights: Design and mechanismPsa-AR (nano-PROTAC) is a modular peptide comprising:– A PSMA-targeting…
How can bioorthogonal chemistry and mitochondrial targeting rewrite cancer immunotherapy? By creating enzyme-responsive nanoparticles that self-assemble in tumors and chemically “click” with an arsenic payload, scientists achieved complete tumor eradication and durable immune memory. Two main components – two small molecules (Fig. panel b)π ππ«π¨ππ π-πππ-πππ:An ALP-responsive small molecule comprising a phosphate-caged fluorophore (mCy), a…