Researchers often steer the design of CRBN-based PROTACs to achieve selective degradation of a single target while suppressing degradation of CRBN neo-substrates. Two different research groups published independently two publications where they approached this differently. By intentional design they developed dual degraders by combining the principles of PROTACs and molecular glue degraders. The first work…
It doesn’t happen very often to see a direct comparison of a molecular glue degrader and PROTAC, as it has been just published in J Med Chem: “๐๐ช๐ด๐ค๐ฐ๐ท๐ฆ๐ณ๐บ ๐ฐ๐ง ๐ข ๐๐ฆ๐ญ๐ฆ๐ค๐ต๐ช๐ท๐ฆ ๐ข๐ฏ๐ฅ ๐๐ฐ๐ต๐ฆ๐ฏ๐ต ๐๐๐6 ๐๐๐๐๐๐ ๐ธ๐ช๐ต๐ฉ ๐๐ง๐ง๐ช๐ค๐ข๐ค๐ช๐ฐ๐ถ๐ด ๐๐ฏ๐ต๐ช๐ฑ๐ณ๐ฐ๐ญ๐ช๐ง๐ฆ๐ณ๐ข๐ต๐ช๐ท๐ฆ ๐๐ค๐ต๐ช๐ท๐ช๐ต๐บ ๐ง๐ฐ๐ณ ๐ต๐ฉ๐ฆ ๐๐ณ๐ฆ๐ข๐ต๐ฎ๐ฆ๐ฏ๐ต ๐ฐ๐ง ๐๐ช๐ง๐ง๐ถ๐ด๐ฆ ๐๐ข๐ณ๐จ๐ฆ ๐โ๐๐ฆ๐ญ๐ญ ๐๐บ๐ฎ๐ฑ๐ฉ๐ฐ๐ฎ๐ข” Why it is interestingโ๏ธ Glue degraders as well…
How do you study the 90% of proteins that lack small-molecule binding partners? By tagging the protein! The problem is that most tags are too bulky, like trying to study a butterfly ๐ฆ with a bowling ball attached. To address this limitation, researchers at the Broad Institute developed two novel protein tags which were published…