Researchers often steer the design of CRBN-based PROTACs to achieve selective degradation of a single target while suppressing degradation of CRBN neo-substrates. Two different research groups published independently two publications where they approached this differently. By intentional design they developed dual degraders by combining the principles of PROTACs and molecular glue degraders. The first work…
It doesn’t happen very often to see a direct comparison of a molecular glue degrader and PROTAC, as it has been just published in J Med Chem: “𝘋𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘰𝘧 𝘢 𝘚𝘦𝘭𝘦𝘤𝘵𝘪𝘷𝘦 𝘢𝘯𝘥 𝘗𝘰𝘵𝘦𝘯𝘵 𝘉𝘊𝘓6 𝘗𝘙𝘖𝘛𝘈𝘊 𝘸𝘪𝘵𝘩 𝘌𝘧𝘧𝘪𝘤𝘢𝘤𝘪𝘰𝘶𝘴 𝘈𝘯𝘵𝘪𝘱𝘳𝘰𝘭𝘪𝘧𝘦𝘳𝘢𝘵𝘪𝘷𝘦 𝘈𝘤𝘵𝘪𝘷𝘪𝘵𝘺 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘛𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵 𝘰𝘧 𝘋𝘪𝘧𝘧𝘶𝘴𝘦 𝘓𝘢𝘳𝘨𝘦 𝘉‑𝘊𝘦𝘭𝘭 𝘓𝘺𝘮𝘱𝘩𝘰𝘮𝘢” Why it is interesting✔️ Glue degraders as well…
How do you study the 90% of proteins that lack small-molecule binding partners? By tagging the protein! The problem is that most tags are too bulky, like trying to study a butterfly 🦋 with a bowling ball attached. To address this limitation, researchers at the Broad Institute developed two novel protein tags which were published…