DNA-encoded libraries

  • From DNA Code to Chemistry

    ByAmbrosigen

    Sumon Pratihar, Eric T. Kool and his team from Stanford University just published new paper in ๐˜ˆ๐˜ฏ๐˜จ๐˜ฆ๐˜ธ๐˜ข๐˜ฏ๐˜ฅ๐˜ต๐˜ฆ ๐˜Š๐˜ฉ๐˜ฆ๐˜ฎ๐˜ช๐˜ฆ, unlocking a new way of selective RNA modification: “๐˜š๐˜ฆ๐˜ฒ๐˜ถ๐˜ฆ๐˜ฏ๐˜ค๐˜ฆ-๐˜š๐˜ฑ๐˜ฆ๐˜ค๐˜ช๐˜ง๐˜ช๐˜ค ๐˜๐˜ฏ๐˜ด๐˜ต๐˜ข๐˜ญ๐˜ญ๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜ฐ๐˜ง ๐˜ˆ๐˜ณ๐˜บ๐˜ญ ๐˜Ž๐˜ณ๐˜ฐ๐˜ถ๐˜ฑ๐˜ด ๐˜ช๐˜ฏ ๐˜™๐˜•๐˜ˆ ๐˜ท๐˜ช๐˜ข ๐˜‹๐˜•๐˜ˆ-๐˜Š๐˜ข๐˜ต๐˜ข๐˜ญ๐˜บ๐˜ด๐˜ต ๐˜Š๐˜ฐ๐˜ฏ๐˜ซ๐˜ถ๐˜จ๐˜ข๐˜ต๐˜ฆ๐˜ด” Key innovationDNA-directed approach that utilizes a DNA oligonucleotide carrying a nucleophilic amine to promote site-selective SNAr reaction at RNA…

  • Curious How Drug Discovery Can Be Accelerated by DELโ€‘ML?

    ByAmbrosigen

    Then I would like to invite you to read our paper in RSC Chem. Biol. which also represents my first corresponding authorship: “๐˜‹๐˜ช๐˜ด๐˜ค๐˜ฐ๐˜ท๐˜ฆ๐˜ณ๐˜บ ๐˜ฐ๐˜ง ๐˜ข๐˜ฏ ๐˜ฆ๐˜น๐˜ฒ๐˜ถ๐˜ช๐˜ด๐˜ช๐˜ต๐˜ฆ๐˜ญ๐˜บ ๐˜ด๐˜ฆ๐˜ญ๐˜ฆ๐˜ค๐˜ต๐˜ช๐˜ท๐˜ฆ ๐˜ž๐˜‹๐˜™5 ๐˜ค๐˜ฉ๐˜ฆ๐˜ฎ๐˜ช๐˜ค๐˜ข๐˜ญ ๐˜ฑ๐˜ณ๐˜ฐ๐˜ฃ๐˜ฆ ๐˜ข๐˜ค๐˜ค๐˜ฆ๐˜ญ๐˜ฆ๐˜ณ๐˜ข๐˜ต๐˜ฆ๐˜ฅ ๐˜ฃ๐˜บ ๐˜ข ๐˜ฉ๐˜ช๐˜จ๐˜ฉ-๐˜ฒ๐˜ถ๐˜ข๐˜ญ๐˜ช๐˜ต๐˜บ ๐˜‹๐˜Œ๐˜“โ€“๐˜”๐˜“ ๐˜๐˜ช๐˜ต” (DEL-ML = DNA Encoded Library + Machine Learning) Highlightsโœ… We demonstrate power of DEL-ML and how it can accelerate…

  • Let it GLOW: Novel Proximity Inducing Modality for DNA Modification

    ByAmbrosigen

    DNA methyltransferases (MTases) can recognize specific DNA sequences and transfer a methyl group from the S-adenosyl-L-methionine (SAM) cofactor to a target nucleobase. This ability has been exploited for sequence-specific DNA labeling using synthetic SAM analogues (SMILing, mTAG). However, both approaches (SMILing and mTAG) share following limitations:๐Ÿ”ธ The SAM analogues are chemically reactive (labile aziridine rings…