Development of Biologically Active Compounds
Your success is our commitment
Our passion for science is your advantage
Early Drug Discovery and Medicinal Chemistry
Did you identify a novel therapeutic target and need help with probing its druggability and finding small molecule ligands?
Or is you drug discovery program in full swing but your team is overloaded and you need to outsource some tasks?
We are ready to support your projects across the early drug discovery pipeline: Screening
Hit identification and validation
Hit to lead development and lead optimization
Structure based drug design and SAR development
Med-chem optimization is like solving a rubic cube, but with long list of parameters instead of colors. Through data- and hypothesis-driven approach we will help you improve:
- Physico-chemical properties
- Potency and selectivity
- Stability and solubility
- Bioavailability
- Safety and Efficacy
- Pharmacokinetics and pharmacodynamics
- Patentability
Targeted Protein Degradation and Induced Proximity
Do you need to develop a degrader for your biological target or support for your proximity inducing modalities? We offer our extensive experience in TPD and induced proximity to support you with:
- Assessing degradability of your target
- Development of novel degraders for your biological target
- Selecting a suitable E3 ligase and warheards for your PROTAC project
- Development of assays and biological profiling
- Proteom wide profiling of your degraders using MS-proteomics
- Mechanistic investigation to understand or validate the mode of action
- Optimization of the potency and physicochemical properties of your bRo5 molecules
Chemical Probes, Tools Compounds, Tracers
Selection of high quality tool compounds, chemical probes and tracers is often underestimated, yet essential for obtaining high quality data and meaningful results. We can assist you with:
- Selecting the best available tool compounds, chemical probes and tracers to address you scientific questions and develop your assays
- Advise you on where to acquire them to balance speed, quality and price.
- Custom synthesis If they are published but not commercially available
- Development of novel (selective) chemical probes, tool compounds or tracers designed for your specific needs
Would you like to discuss how we can support your project?
Or would you like to become part of our scientific network as external partner?
Book a free consultation and explore if we are a good fit for each other