Chemical Biology

  • Group-Transfer Chimeras for Induced Proximity (GRIPs)

    ByAmbrosigen

    Induced proximity is more than ubiquitination and targeted protein degradation. In the recent literature we have seen proximity-inducing modalities for phosphorylation and dephosphorylation, deubiquitination, glycosylation and more. 𝗖𝘂𝗿𝗿𝗲𝗻𝘁 𝗹𝗶𝗺𝗶𝘁𝗮𝘁𝗶𝗼𝗻However, when we induce proximity between our protein of interest (POI) and an effector protein, it can be counterproductive to use inhibitory ligands for recruitment of the…

  • A Biocompatible Lossen Rearrangement in Escherichia Coli

    ByAmbrosigen

    Forget your fume hood, E. coli just became your new reaction vessel 💡 What’s new?Researchers have shown that a classic organic transformation (the Lossen rearrangement) runs smoothly inside E. coli cells. The reaction uses only phosphate as a catalyst, so no engineered enzyme is needed. By converting a specially activated precursor into para-aminobenzoic acid (PABA), the reaction restores growth to an E. coli strain that cannot…