Development of Biologically Active Compounds

Your success is our commitment

Our passion for science is your advantage

Small Molecule Drug Discovery and Medicinal Chemistry

Did you identify a novel therapeutic target and need help with probing its druggability and finding small molecule ligands?

Or is you drug discovery program in full swing but your team is overloaded and you need to outsource some tasks?

We are ready to support your projects across the early drug discovery pipeline:

  • Screening
  • Hit identification and validation
  • Hit to lead development and lead optimization
  • Structure based drug design and SAR development

Med-chem optimization is like solving a Rubik’s cube, but with long list of parameters instead of colors. Through data- and hypothesis-driven approach we will help you improve:

  • Physico-chemical properties
  • Potency and selectivity
  • Stability and solubility
  • Bioavailability
  • Safety and Efficacy
  • Pharmacokinetics and pharmacodynamics
  • Patentability

Targeted Protein Degradation and Induced Proximity

Do you need to develop a degrader for your biological target or support for your proximity inducing modalities? We offer our extensive experience in TPD and induced proximity to support you with:

  • Assessing degradability of your target
  • Development of novel degraders for your biological target
  • Selecting a suitable E3 ligase and warheads for your PROTAC project
  • Development of assays and biological profiling
  • Proteom-wide profiling of your degraders using MS-proteomics
  • Mechanistic investigation to understand or validate the mode of action
  • Optimization of the potency and physicochemical properties of your bRo5 molecules

Chemical Probes, Tool Compounds, Tracers

Selection of high quality tool compounds, chemical probes and tracers is often underestimated, yet essential for obtaining high quality data and meaningful results. We can assist you with:

  • Selecting the best available tool compounds, chemical probes and tracers to address your scientific questions and develop your assays
  • Advise you on where to acquire them to balance speed, quality and price.
  • Custom synthesis If they are published but not commercially available
  • Development of novel (selective) chemical probes, tool compounds or tracers designed for your specific needs

Would you like to discuss how we can support your project?

Or would you like to become part of our scientific network as external partner?

Book a free consultation and explore if we are a good fit for each other

Book a free consultation